
Overview:
HTRA4 is a serine protease with a conserved trypsin domain and a PDZ domain.As other related family members, HTRA4 may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. HrtA4 may contribute to shallow trophoblast invasion in preeclampsia (1) and imply a potential application as a biomarker for this disorder (2).
Gene Aliases:
None
Genbank Number:
NM_153692
References:
1.Wang LJ. et.al:High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. Mol Cell Biol. 2012 Sep;32(18):3707-17. 2.Inagaki A. et.al:Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. Placenta. 2012 Nov;33(11):919-26.
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一抗的英语是 resistance No.1,二抗resistance No.2.
想通过亲和层析来纯化抗血小板特异性抗体(抗GPIIb/IIIa抗体和抗GPIbα抗体),能否做到呢?谢谢!

