| Guanidinoethyl sulfonatecompetitive glycine receptor antagonist |
Sample solution is provided at 25 µL, 10mM.
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| Cas No. | 543-18-0 | SDF | Download SDF |
| Synonyms | NSC 667063,Taurocyamine | ||
| Chemical Name | 2-[(aminoiminomethyl)amino]-ethanesulfonic acid | ||
| Canonical SMILES | OS(CCNC(N)=N)(=O)=O | ||
| Formula | C3H9N3O3S | M.Wt | 167.2 |
| Solubility | ≤1mg/ml in PBS | Storage | Store at -20°C |
| Physical Appearance | A crystalline solid | Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
Guanidinoethyl sulfonate is a competitive glycine receptor antagonist.
The glycine receptor, the receptor for the amino acid neurotransmitter glycine, is an ionotropic receptor producing its effects via chloride current. Glycine receptor is one of the most widely distributed inhibitory receptors in the central nervous system and has important roles in various physiological processes.
In vitro: Guanidinoethyl sulphonate was found to be an analogue of taurine and an inhibitor of taurine transport. Guanidinoethyl sulphonate was also shown to be a weak agonist at GABA(A) receptors, and was able to antagonize GABA-evoked responses. Guanidinoethyl sulphonate did not gate GlyR. 3. but antagonized glycine responses in a concentration-dependent and surmountable manner. Glycine receptor-mediated taurine responses were competitively antagonized by guanidinoethyl sulphonate. Taurine dose-response curves, in contrast to the glycine dose-response curves were shifted by guanidinoethyl sulphonate to the right in a parallel manner [1].
In vivo: Guanidinoethyl sulphonate delivered in the drinking water of rats for 1 month could effectively reduce taurine levels in brain structures and outside the brain by between 50 and 80 %, depending on the tissue. This partial taurine depletion could not affect either basal synaptic transmission or the late phase of long-term potentiation in hippocampal slices. In-vivo microdialysis studies in the hippocampus demonstrated that guanidinoethyl sulphonate was able to reduce extracellular taurine levels and the magnitude of taurine released in response to the application of either N-methyl-D-aspartate or a hypoosmotic solution [2].
Clinical trial: So far, no clinical study has been conducted.
References:[1] Sergeeva, O. A.,Chepkova, A.N., and Hass, H.L. Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum. British Journal of Pharmacology 137, 855-860 (2002).[2] Suárez LM, Muoz MD, González JC, Bustamante J, Del Río RM, Solís JM. The taurine transporter substrate guanidinoethyl sulfonate mimics the action of taurine on long-term synaptic potentiation. Amino Acids. 2016 Nov;48(11):2647-2656. Epub 2016 Jul 15.
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师兄说每次一定要两块胶一起跑电泳才能形成回路，但是制胶因为只有一个制胶架，就只能分两次弄
想问一下一般都是这样的吗？还有加了浓缩胶插了梳子之后一定要等2h才能让胶充分凝固吗？
小弟这个学期开学以来，电泳槽的液体因为假期无人看管就干了，我用了酒精冲洗好几遍后，电泳槽泡出来的电泳就一直有问题，当你第一次用新电泳液跑的时候还比较好，但是用了两三次之后就会摸带，需要极其频繁的更换电泳液，纯水消耗量极大，请问各位大神如何修复？
TIF格式的图片无法上传。。。。如果需要图片我再转格式发过来，谢谢各位。
