
Helioxanthinnovel inhibitor of HBV, HCV and HSV-1 virus |
Sample solution is provided at 25 µL, 10mM.
































Quality Control & MSDS
- View current batch:
- Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure


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Cas No. | 18920-47-3 | SDF | Download SDF |
Canonical SMILES | N/A | ||
Formula | C20H12O6 | M.Wt | 348.31 |
Solubility | Soluble in DMSO | Storage | Store at -20°C |
Shipping Condition | Evaluation sample solution : ship with blue ice.All other available size:ship with RT , or blue ice upon request | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
Helioxanthin (ACH126447) is a novel inhibitor of HBV, HCV and HSV-1 virus with EC50 values of 1 μM, 3 μM and 2 μM, respectively [1].
Helioxanthin has shown significant antiviral effect on HBV, HCV and HSV-1 virus in vitro with EC50 values of 1 μM, 3 μM and 2 μM, respectively. In a cell culture model, the level of HBV RNA, the expression of HBV antigen and its replication were all reduced by helioxanthin. Besides, helioxanthin has been exhibited to have a low cytotoxicity on both MT-223 and CEM24 cell lines with ID50 values of 2.5 μM and 31 μM, respectively [1].
Reference:[1] Yeo H1, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC.Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27;48(2):534-46.
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因为DNA和RNA链上的碱基都基本一致。而这两种上样缓冲液中含有的染料是二甲苯青和溴酚蓝,都可以与其碱基结合,跑出条带。
但是,如果使用DNA上样缓冲液,里面会夹杂一些RNA酶,这些酶有可能会影响到实验结果。使用前需要将RNA酶处理掉。
1mol/l Tirs-HCl(PH8.8) 0.6ml
10%SDS 2ml
50%甘油 5ml
2-巯基乙醇 0.5ml
1%溴酚兰 1ml
水 0.9ml
另外:SDS不好溶解建议加热溶解,如果要做非还原SDS-PAGE请将2-巯基乙醇 0.5ml换成超纯水即可
配制分三步: 1) 1 M Tris-HCl (pH 8.0) 50 ml的配制:称取Tris碱6.06 g,加超纯水40 ml溶解,滴加浓HCl约2.1 ml调pH至8.0,定容至50 ml。

