BackgroundEndothelial cell differentation gene-3 (EDG3) belongs to a family of G-protein couple receptors whose ligands are lysophospholipids.The ligand for EDG3 is sphingosine-1-phosphate.There are 8 known members of the EDG receptor family.They have been implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival suppression of apoptosis.They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.EDG receptors are developmentally regulated and differ in tissue distribution.The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases.EDG3 is expressed in cardiovascular, leukocyte-containing and other tissues.

Product

Product Form: Unconjugated

Formulation: Provided in solution at 1 mg/ml in phosphate buffered saline.

Concentration: See vial for concentration

ApplicationsFor use with EDG3 (S1P3) (CT) polyclonal antibody (Cat. No. X1589P).

Functional Analysis: Western Blotting

StorageProduct should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Product Stability: Products are stable for one year from purchase when stored properly

Shipping Conditions: Ship at ambient temperature, freeze upon arrival

CautionThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.

Protein Reference(s)

Database Name: UniProt

Accession number: Q99500

Species Accession: Human