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Description:Selectivep300inhibitor
ChemicalName:S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzymeAtrifluoroacetate
Purity:≥95%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Selectivep300histoneacetyltransferase(HAT)inhibitor(IC50=50-500nM).Exhibitsapproximately100-foldselectivityforp300overPCAF(IC50=200μM).Inhibitsp300-dependenttranscription.Activeinvivo.
TechnicalData
| M.Wt | 1108.82 |
| Formula | C31H53N10O19P3S.C2HF3O2 |
| Storage | Storeat-20°C |
| Purity | ≥95%(HPLC) |
| Smiles | O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 6.99 | 6.3 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1108.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.9mL | 4.51mL | 9.02mL |
| 5mM | 0.18mL | 0.9mL | 1.8mL |
| 10mM | 0.09mL | 0.45mL | 0.9mL |
| 50mM | 0.02mL | 0.09mL | 0.18mL |
MolarityCalculator
MolarityCalculator
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ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.
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