
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllThegalectinsareafamilyofbeta-galactoside-bindingproteinsimplicatedinmodulatingcell-cellandcell-matrixinteractions.Galectin-1isanautocrinenegativegrowthfactorthatregulatescellproliferation.Galectin-1regulatescellapoptosisandcelldifferentiation.Galectin-1bindsCD45,CD3andCD4&inhibitsCD45proteinphosphataseactivityandthereforethedephosphorylationoflynkinase.Galectin-1anditsligandsareoneofthemasterregulatorsofimmuneresponsesasT-cellhomeostasisandsurvival,T-cellimmunedisorders,inflammationandallergiesaswellashost–pathogeninteractions.Galectin-1expressionoroverexpressionintumorsand/orthetissuesurroundingthemmustbeconsideredasasignofthemalignanttumorprogressionthatisoftenrelatedtothelong-rangedisseminationoftumoralcells(metastasis),totheirdisseminationintothesurroundingnormaltissue,andtotumorimmune-escape.Galectin-1initsoxidizedformplaysanumberofimportantrolesintheregenerationofthecentralnervoussystemafterinjury.Thetargetedoverexpression(ordelivery)ofGalectin-1shouldbeconsideredasamethodofchoiceforthetreatmentofsomekindsofinflammation-relateddiseases,neurodegenerativepathologiesandmusculardystrophies.Incontrast,thetargetedinhibitionofGalectin-1expressioniswhatshouldbedevelopedfortherapeuticapplicationsagainstcancerprogression.Galectin-1isthusapromisingmoleculartargetforthedevelopmentofnewandoriginaltherapeutictools.Thereis88%homologybetweenthehumanandmousegalectin-1
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NaturalProteinStopsDeadlyHumanBrainCancerInMice
ScientistsfromJohnsHopkinsandfromtheUniversityofMilanhaveeffectivelyproventhattheycaninhibitlethalhumanbraincancersinmiceusingaproteinthatselectivelyinducespositivechangesintheactivityofcellsthatbehavelikecancerstemcells.ThereportispublishedinNature.
Themostcommontypeofbraincancer-glioblastoma-ismarkedbythepresenceofthesestem-cell-likebraincells,which,insteadoftriggeringthereplacementofdamagedcells,formcancertissue.Stemcells,unlikeallothercellsinthebody,arecapableofformingalmostanykindofcellwhentheright"signals"triggertheirdevelopment.
Fortheirtreatmentexperiment,theresearchersreliedonaclassofproteins,bonemorphogenicproteins,thatcauseneuralstem-cell-likeclusterstolosetheirstemcellproperties,whichinturnstopstheirABIlitytodivide.
Firsttheypretreatedhumanglioblastomacellswithbonemorphogenicprotein4(BMP4),theninjectedthesetreatedcellsintomousebrains.Inmiceinjectedwithcellsthatwerenotpretreated,large,invasivecancersgrew.InthemicewithBMP4-treatedcells,nocancersgrewatall.Threetofourmonthsafterinjection,allmicethatgotuntreatedcellsdied,andnearlyallmicewithBMP4-treatedcellswerealive.
Next,thescientistsdeliveredslow-releaseBMP4-containing"beads"directlyintomousebrainswithimplantedglioblastomacells.Micethatgotemptybeadsdevelopedlargemalignanttumorsanddied.MicewithBMP4beadssurvivedmuchlonger,and80percentsurvivedfourmonthsaftercancercellimplants.
"OurideaistotreatpatientswithBMP4orsomethinglikeitrightaftersurgerytoremoveglioblastomainhopesofpreventingtheregrowthofthecancerandimprovingsurvivaltime,"saysAlessandroOlivi,M.D.,directoroftheDivisionofNeurosurgicalOncologyatHopkinsandacontributortothestudy.
OlivisaysclinicalstudiesusingBMP4couldbeginwithinayearand,ifsuccessful,drugtherapiescouldbeavailabletothepublicwithinthreetofouryears.
"ThiswasproofoftheideathatBMPscouldstopglioblastomabydepletingthestem-cell-likepopulationthatfeedsit,"saysHenryBrem,M.D.,chairmanoftheDepartmentofNeurosurgeryatHopkinsandacollaboratorinthestudy."Thisopensexcitingdoorstofutureresearchintotreatmentsandtherapiesforsuchadevastatingdisease."
本人目前需从电鳗放电器官中提取乙酰胆碱受体蛋白,提纯需要的步骤和电鳗器官都可以提供,有没有提供外包提纯服务的公司或者实验室。

