BiologicalActivity
Selectivetelomeraseinhibitor(IC50valuesare93,>100000and>100000nMforhumantelomerase,humanRNApolymeraseIandhumanRNApolymeraseII+IIIrespectively).CausestelomereshorteninginexponentiallygrowingNCI-H460lungcarcinomacellsandeventualgrowtharrest.
CompoundLibraries
BIBR1532isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 331.36 |
| Formula | C21H17NO3 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 321674-73-1 |
| PubChemID | 9927531 |
| InChIKey | PGFQXGLPJUCTOI-WYMLVPIESA-N |
| Smiles | C/C(C2=CC1=CC=CC=C1C=C2)=CC(NC3=C(C(O)=O)C=CC=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.14 | 100 | |
| ethanol | 8.28 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight331.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.02mL | 15.09mL | 30.18mL |
| 5mM | 0.6mL | 3.02mL | 6.04mL |
| 10mM | 0.3mL | 1.51mL | 3.02mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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