品牌试剂实验Tocris代理 Tocris Bioscience产品目录价格,Tocris/BYK 49187/3735/1/1 mg,DNA聚合酶,核酸酶类,分子类,,Tocris Bioscience蚂蚁淘商城

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Tocris/BYK 49187/3735/1/1 mg

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Tocris

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3735/1

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4000-520-616

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Description:PARP-1andPARP-2inhibitor

ChemicalName:4,5-Dihydro-2-[4-(4-methyl-1H-imidazol-4-yl)-1-piperidinyl]-6H-imidazo[4,5,1-ij]quinolin-6-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PARP-1andPARP-2inhibitor(pIC₅₀valuesare8.36and7.50forcell-freerecombinantPARP-1andmurinePARP-2respectively).DisplayspotentinhibitoryactivityagainsthumanPARP-1incell-freeandcellularassaysinvitro;reducesmyocardialinfarctsizeinvivo.

TechnicalData

M.Wt	335.4
Formula	C₁₉H₂₁N₅O
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	163120-31-8
PubChemID	15285131
InChIKey	YKJJROIKVYSPDH-UHFFFAOYSA-N
Smiles	O=C2CCN3C1=C(N=C3N4CCC(C5=C(C)N=CN5)CC4)C=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	3.35	10
	ethanol	16.77	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight335.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.98mL	14.91mL	29.82mL
5mM	0.6mL	2.98mL	5.96mL
10mM	0.3mL	1.49mL	2.98mL
50mM	0.06mL	0.3mL	0.6mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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