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Description:PARP-1andPARP-2inhibitor
ChemicalName:1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Competitiveinhibitorofpoly(ADP-ribose)polymerase(PARP)(IC50valuesare0.20and0.24μMforPARP-1andPARP-2respectively).Neuroprotective;reducesneuronalcelldeathinmodelsofcerebralischemiainvivoandinvitro.Brainpenetrant.
TechnicalData
M.Wt | 182.24 |
Formula | C8H10N2OS |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 284028-90-6 |
PubChemID | 10219702 |
InChIKey | HRYKZAKEAVZGJD-UHFFFAOYSA-N |
Smiles | CC1=NC(=O)C2=C(N1)CCSC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 7.29 | 40 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight182.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 5.49mL | 27.44mL | 54.87mL |
5mM | 1.1mL | 5.49mL | 10.97mL |
10mM | 0.55mL | 2.74mL | 5.49mL |
50mM | 0.11mL | 0.55mL | 1.1mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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