BiologicalActivity
Non-nucleosidereversetranscriptaseinhibitor(NNRTI).SelectivelyinhibitsHIV-1reversetranscriptase(RNA-dependentDNApolymerase)overothercellularpolymerases(IC50valuesare0.26,440and>550μMforHIV-1reversetranscriptase,DNApolymeraseαandDNApolymeraseδ).PreventsHIV-1spreadinvivoandblocksviralreplicationinperipheralbloodlymphocytes.Orallyactive.
LicensingInformation
SoldforresearchpurposesunderagreementfromViiv.
CompoundLibraries
DelavirdinemesylateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 552.67 |
| Formula | C22H28N6O3S.CH3SO3H |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 147221-93-0 |
| PubChemID | 441386 |
| InChIKey | MEPNHSOMXMALDZ-UHFFFAOYSA-N |
| Smiles | O=C(N3CCN(C4=NC=CC=C4NC(C)C)CC3)C2=CC1=CC(NS(=O)(C)=O)=CC=C1N2.CS(O)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.45 | 75 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight552.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.81mL | 9.05mL | 18.09mL |
| 5mM | 0.36mL | 1.81mL | 3.62mL |
| 10mM | 0.18mL | 0.9mL | 1.81mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |
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