BiologicalActivity
InhibitorofPARP-3(IC50=0.89μM).DisplaysselectivityforPARP-3overPARP-1,PARP-2andotherARDTenzymes(IC50valuesare6.3,10.8and>30μMrespectively).EnhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.Cellpermeable.
CompoundLibraries
ME0328isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 321.37 |
| Formula | C19H19N3O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1445251-22-8 |
| PubChemID | 71571526 |
| InChIKey | QIHBWVVVRYYYRO-ZDUSSCGKSA-N |
| Smiles | O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.11mL | 15.56mL | 31.12mL |
| 5mM | 0.62mL | 3.11mL | 6.22mL |
| 10mM | 0.31mL | 1.56mL | 3.11mL |
| 50mM | 0.06mL | 0.31mL | 0.62mL |
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