BiologicalActivity
Inhibitorofpoly(ADP-ribose)polymerase(PARP)(IC50=9.5μM);displaysmixedinhibitionwithrespecttoNAD+.Protectiveagainstischemia-reperfusioninducedROSproduction,andsubsequentmitochondrialandcelldamageinratheart.Anti-inflammatoryinLPS-inducedendotoxicmiceinvivo;decreasesNF-κBandAP-1activation.
TechnicalData
| M.Wt | 146.15 |
| Formula | C8H6N2O |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 491-36-1 |
| PubChemID | 63112 |
| InChIKey | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
| Smiles | OC1=C2C=CC=CC2=NC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.62 | 100 | |
| water | 1.46 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight146.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 6.84mL | 34.21mL | 68.42mL |
| 5mM | 1.37mL | 6.84mL | 13.68mL |
| 10mM | 0.68mL | 3.42mL | 6.84mL |
| 50mM | 0.14mL | 0.68mL | 1.37mL |
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