BiologicalActivity
Potenttankyrase(TNKS)inhibitor(IC50valuesare4and11nMforTNKS2andTNKS1respectively).AntagonizesWntsignalingviastimulationofβ-catenindegradationandstABIlizationofaxin.Inhibitsproliferationoftheβ-catenin-dependentcoloncarcinomacelllineDLD-1.PromotescardiomyogenicdevelopmentinmesodermProgenitorcells.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofXAV939isreviewedonthechemicalprobeswebsite.
CompoundLibraries
XAV939isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 312.31 |
| Formula | C14H11F3N2OS |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 284028-89-3 |
| PubChemID | 2726824 |
| InChIKey | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
| Smiles | OC1=C(CSCC2)C2=NC(C3=CC=C(C(F)(F)F)C=C3)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.25 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight312.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.2mL | 16.01mL | 32.02mL |
| 5mM | 0.64mL | 3.2mL | 6.4mL |
| 10mM | 0.32mL | 1.6mL | 3.2mL |
| 50mM | 0.06mL | 0.32mL | 0.64mL |
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