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Tocris/WIKI4/4855/50/50 mg
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Tocris/WIKI4/4855/50/50 mg
品牌 / 
Tocris
货号 / 
4855/50
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4000-520-616
Description:Potenttankyraseinhibitor
ChemicalName:2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofWnt/β-cateninsignaling(EC50~75nM).Inhibitsauto-ADP-ribosylationoftankyrase2(TNKS2)(IC50~15nM);preventstheubiquitinationanddegradationofaxin.

CompoundLibraries

WIKI4isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt521.59
FormulaC29H23N5O3S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber838818-26-1
PubChemID2984337
InChIKeyRNUXIZKXJOGYQP-UHFFFAOYSA-N
SmilesO=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO10.4320

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight521.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.92mL9.59mL19.17mL
5mM0.38mL1.92mL3.83mL
10mM0.19mL0.96mL1.92mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet