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Description:Potenttankyraseinhibitor
ChemicalName:2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
InhibitorofWnt/β-cateninsignaling(EC50~75nM).Inhibitsauto-ADP-ribosylationoftankyrase2(TNKS2)(IC50~15nM);preventstheubiquitinationanddegradationofaxin.
CompoundLibraries
WIKI4isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 521.59 |
Formula | C29H23N5O3S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 838818-26-1 |
PubChemID | 2984337 |
InChIKey | RNUXIZKXJOGYQP-UHFFFAOYSA-N |
Smiles | O=C(C5=C4C(C6=O)=CC=CC4=CC=C5)N6CCCSC1=NN=C(C3=CC=NC=C3)N1C2=CC=C(OC)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 10.43 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight521.59.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.92mL | 9.59mL | 19.17mL |
5mM | 0.38mL | 1.92mL | 3.83mL |
10mM | 0.19mL | 0.96mL | 1.92mL |
50mM | 0.04mL | 0.19mL | 0.38mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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