BiologicalActivity
E2ubiquitin(Ub)conjugatingenzymeinhibitor.InhibitstheconjugationofUbtoarangeofE2enzymes.InhibitsE2enzymemediatedIκBαphosphorylationandindirectlydecreasesNF-κbactivity.AlsoreversIBLyactivatesMAPKsignaling.InducesapoptosisofleukemicTcellandB-celllymphomacelllines.AlsoinhibitsactivationofNLRP3inflammasome.
TechnicalData
| M.Wt | 207.25 |
| Formula | C10H9NO2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 19542-67-7 |
| PubChemID | 5353431 |
| InChIKey | DOEWDSDBFRHVAP-KRXBUXKQSA-N |
| Smiles | CC1=CC=C(C=C1)S(=O)(=O)C=CC#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.73 | 100 | |
| ethanol | 5.18 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight207.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.83mL | 24.13mL | 48.25mL |
| 5mM | 0.97mL | 4.83mL | 9.65mL |
| 10mM | 0.48mL | 2.41mL | 4.83mL |
| 50mM | 0.1mL | 0.48mL | 0.97mL |
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