Xcessbio/L755,507, CRISPR Editing Enhancer-Xcessbio Biosciences Inc/10 mg solid/M60237-10s_蚂蚁淘，【正品极速】生物医学科研用品轻松购|ebiomall 蚂蚁淘商城

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Xcessbio/L755,507, CRISPR Editing Enhancer-Xcessbio Biosciences Inc/10 mg solid/M60237-10s

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Xcessbio/L755,507, CRISPR Editing Enhancer-Xcessbio Biosciences Inc/10 mg solid/M60237-10s

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Xcess Biosciences Inc

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M60237-10s

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4000-520-616

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ProductInformation

MolecularWeight:	584.73
Formula:	C₃₀H₄₀N₄O₆S
Purity:	≥98%
CAS#:	159182-43-1
Solubility:	DMSOupto100mM
ChemicalName:	(S)-4-(3-hexylureido)-N-(4-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)phenyl)benzenesulfonamide
Storage:	Powder:4^oC1year.DMSO:4^oC3month;-20^oC1year.

BIOLOGicalActivity:

L-755,507waspreviouslycharacterizedasapotentandselectiveβ3adrenergicreceptorpartialagoNISTwithEC₅₀~0.43nM.Ithas>1000foldselectivityoverβ1-andβ2-adrenoceptors(EC₅₀~580nMand>10000nMforβ1-andβ2-adrenoceptorsrespectively).ItstimulateslipolysisinrhesusADIpocytesinvitro(EC₅₀=3.9nM).Inarecentstudy,L-755,507wasidentifiedtoenhanceCRISPR-mediatedhomology-directedrepair(HDR)efficiencyinhumaninducedpluripotentstemcells(iPSCs)andothercelltypes.

HowtoUse:

Invitro:L-755,507wasusedat1-5µMfinalconcentrationinvariousinvitroassays.

Invivo:L-755,507stimulatesmetabolicrateby30%afteracutebolusintravenousadministrationof0.1mg/kgtorhesusmonkeys.

Reference:

1.FisherMH,etal.Aselectivehumanbeta3adrenergicreceptoragonistincreasesmetabolicrateinrhesusmonkeys.(1998)JClinInvest.101(11):2387-93.
2.ParmeeER,etal.DiscoveryofL-755,507:asubnanomolarhumanbeta3adrenergicreceptoragonist.(1998)BioorgMedChemLett.8(9):1107-12.
3.YuC,etal.SmallMoleculesEnhanceCRISPRGenomeEditinginPluripotentStemCells.(2015)CellStemCell16(2):142-7.

L755507_spec.pdf

L755507_MSDS.pdf

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