BiologicalActivity
Potentγ-secretaseinhibitor(IC50valuesare1.2and6.2nMinwholecellandcell-freeassays,respectively).ReducesAβinbrain,CSFandplasmainmiceandguineapigs.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 651.47 |
| Formula | C27H41F2N5O.HBr |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1962925-29-6 |
| PubChemID | 121513889 |
| InChIKey | LXEYYZYDWLAIPW-KBVFCZPLSA-N |
| Smiles | O=C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)[C@H](CCC)N[C@H]2CCC1=CC(F)=CC(F)=C1C2.Br.Br |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 65.15 | 100 | |
| water | 6.51 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight651.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.53mL | 7.67mL | 15.35mL |
| 5mM | 0.31mL | 1.53mL | 3.07mL |
| 10mM | 0.15mL | 0.77mL | 1.53mL |
| 50mM | 0.03mL | 0.15mL | 0.31mL |
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