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Apotent,reversIBLe,cellpermeableandspecificinhibitorofATPaseofp97(alsocalledvalosin-containingprotein(VCP))withIC50of1.5μM.DBeQinhibitsbothubiquitin-dependentandautophagicproteindegradationpathwaysandrapidlyinducescaspases-3and-7activityandapoptosis.
AdditionalInformation
ProductName: | DBeQ |
---|---|
AlsoKnownAs: | N²,N⁴-Dibenzylquinazoline-2,4-diamine;CAS#177355-84-9;C₂₂H₂₀N₄ |
CatalogNo.: | F1420 |
Size: | 5mg |
MolecularWeight: | 340.42Da |
Species: | N/A |
Source: | Synthetic |
Stock: | Powder |
Concentration: | N/A |
QualityAssurance: | ≥98%byHPLC |
Storage: | Eligibleforroomtemperatureshipping.Storeat-20°Cuponreceiving;protectfromairandlight |
PDFDataSheet: | PDFDatasheet |
NCBIRefSeq: | N/A |
Image(s): | N/A |
ShippingMethod: | Roomtemperatureshipping |
References: | 1.ChouTF,etal.(2011)ProcNatlAcadSciUSA,108(12),4834-4839.
2.ChouTF,etal.(2011)Autophagy,7(9),1091-1092. |