Overview:
PKCβ II is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol and phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways (1). PKCβ II has been reported to be involved in many different cellular functions such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption (2).
Gene Aliases:
PRKCB1; PKCB2; PRKCB1; PRKCB (X07109)
Genbank Number:
NM_002738
References:
1.Greenham, J. et al: Elucidation of the exon-intron structure and size of the human protein kinase C beta gene (PRKCB). Hum. Genet. 103: 483-487, 1998.2.Su, T T. et al: PKC-beta controls I-kappa-B kinase lipid raft recruitment and activation in response to BCR signaling. Nature Immun. 3: 780-786, 2002.
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没有序列识别的功能,他就是简单的催化相邻DNA链的5-P末端和3'-OH末端以磷酸二酯键结合的反应,需ATP作辅酶。 不仅可以催化粘性末端之间或平滑末端之间的DNA的连接,也催化DNA与RNA之间以及少数RNA之间的连接。
反转录酶(Reversetranscripatase)是以RNA为模板指导三磷酸脱氧核苷酸合成互补DNA(cDNA)的酶。哺乳类C型病毒的反转录酶和鼠类B型病毒的反转录酶都是一条多肽链。鸟类RNA病毒的反转录酶则由两上亚基结构。真核生物中也都分离出具有不同结构的反转录酶。
TERT是端粒酶逆转录酶
人的端粒酶是由端粒酶逆转录酶、端粒酶RNA和一种假尿嘧啶合成酶组成

