BiologicalActivity
Wntcanonicalsignalingactivator.Alsoinhibitstubulinpolymerization.SuppressesTLR2/4/5-inducedinflammatoryresponseinhumanmonocytes.InhibitscellproliferationandinducescellcyclearrestinMDA-MB-231breastcancercells.Alsodecreasesembryotoblastocystdevelopment.
TechnicalData
| M.Wt | 386.84 |
| Formula | C19H18N4O3.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 2095432-75-8 |
| PubChemID | 122705993 |
| InChIKey | XZOFNDFDGVAIEH-UHFFFAOYSA-N |
| Smiles | COC1=CC=CC(C2=NC(N)=NC(NCC3=CC=C4OCOC4=C3)=C2)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.68 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight386.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.59mL | 12.93mL | 25.85mL |
| 5mM | 0.52mL | 2.59mL | 5.17mL |
| 10mM | 0.26mL | 1.29mL | 2.59mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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