Wntglycoproteinsplayaroleindiverseprocessesduringembryonicpatterninginmetazoathroughinteractionwithfrizzled-typeseven-transmembrane-domainreceptors(Frz)tostABIlizeb-catenin.LDL-receptor-relatedprotein6(LRP6),aWntco-receptor,isrequiredforthisinteraction.Dikkopf(dkk)proteinsarebothpositiveandnegativemodulatorsofthissignaling. Contributor:JosephChuang,PhD REFERENCES:BrottBK,SokolSY.RegulationofWnt/LRPsignalingbydistinctdomainsofDickkopfproteins.MolCellBiol.2002Sep;22(17):6100-10.MaoBetal.KremenproteinsareDickkopfreceptorsthatregulateWnt/beta-cateninsignalling.Nature.2002Jun6;417(6889):664-7.MaoBetal.LDL-receptor-relatedprotein6isareceptorforDickkopfproteins.Nature.2001May17;411(6835):321-5.