mesenchymalstemcellslackefficacyinthetreatmentofexperimentalautoimmuneneuritisdespiteinvitroinhibitionoft-cellproliferation间充质干细胞缺乏疗效的治疗实验性自身免疫性神经炎尽管体外抑制t细胞增殖.pdf_淘豆网
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MesenchymalStemCellsLackEfficacyintheTreatment
ofExperimentalAutoimmuneNeuritisdespiteInVitro
InhibitionofT-CellProliferation
..
MarijaSajic1,DavidP.J.Hunt1,2,4*,WoojinLee1,D.AlastairS.Compston2,JudithV.Schweimer3,
NormanA.Gregson1,SiddharthanChandran4,hJ.Smith1
1DepartmentofNeuroinflammation,InstituteofNeurology,UniversityCollegeLondon,London,UnitedKingdom,2DepartmentofClinicalNeurosciences,Universityof
Cambridge,Cambridge,UnitedKingdom,3DepartmentofNeuroimmunology,King’sCollegeLondon,London,UnitedKingdom,4MRCCentreforRegenerativeMedicine,
UniversityofEdinburgh,Edinburgh,UnitedKingdom
Abstract
Mesenchymalstemcellshavebeendemonstratedtoameliorateexperimentalautoimmuneencephalomyelitis(EAE),a
modelofmultiplesclerosis,promptingclinicaltrialsinmultiplesclerosiswhicharecurrentlyongoing.Animportant
questioniswhetherthistherapeuticeffectgeneralisestootherautoimmuneneurologicaldiseases.Weperformedtwotrials
ofefficacyofMSCsinexperimentalautoimmuneneuritis(EAN)inLewis(LEW/HanMHsd)rats,amodelofhuman
autoimmuneinflammatoryneuropathies.Nodifferencesbetweenthegroupswerefoundinclinical,histologicalor
electrophysiologicalemeasures.Thiswasdespitetheabilityofmesenchymalstemcellstoinhibitproliferationof
CD4+T-cellsinvitro.ThereforetheefficacyofMSCsobservedinSdemyelinationmodelsdonotnecessarily
generalisetothetreatmentofotherformsofneurologicalautoimmunity.
Citation:SajicM,HuntDPJ,LeeW,CompstonDAS,SchweimerJV,etal.(2012)MesenchymalStemCellsLackEfficacyintheTreatmentofExperimental
AutoimmuneNeuritisdespiteInVitroInhibitionofT-CellProliferation.PLoSONE7(2):e30708.doi:10.1371/journal.pone.0030708
Editor:PabloVilloslada,InstituteBiomedicalResearchAugustPiSunyer(IDIBAPS)-HospitalClinicofBarcelona,Spain
ReceivedAugust26,2011;AcceptedDecember21,2011;PublishedFebruary16,2012
Copyright:2012Sajicetal.Thisisanopen-accessarticledistributedunderthetermsofthemonsAttributionLicense,whichpermitsunrestricted
use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.
Funding:DHisfundedbyaBrainentrancescholarship(GuarantorsofBrain)andbytheeTrust.KJSisfundedbytheMedicalResearchCouncil,United
Kingdom,theMultipleSclerosisSocietyofGreatBritianNorthernIreland,theEuropeanUnion(FP6NeuroproMiSe)andtheBrainResearchTrust.SCissupported
bytheNationalInstituteforHealthResearchBiomedicalResearch.Thefundershadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,or
preparationofthemanuscript.
CompetingInterests:Theauthorshavedeclaredthatpetinginterestsexist.
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