The PointProbe® Plus (PPP) combines the well-known features of the proven PointProbe® series such as high application versatility and compatibility with most commercial SPMs with a further reduced and more reproducible tip radius as well as a more defined tip shape. The excellent tip radius and the minimized variation in tip shape provide more reproducible images and enhanced resolution.
NANOSENSORS™ PPP-NCSTAuD AFM probes are designed for non-contact or soft tapping mode imaging. The combination of soft cantilever and fairly high resonance frequency enables stable and fast measurements with reduced tip-sample interaction. This feature significantly reduces tip wear and sample wear at the same time.
The probe offers unique features:
excellent tip radius of curvature
highly doped silicon to dissipate static charge
Au coating on detector side of cantilever
chemically inert
A metallic layer (Au) is coated on the detector side of the cantilever which enhances the reflectivity of the laser beam by a factor of about 2.5. Furthermore it prevents light from interfering within the cantilever. The virtually stress-free coating is bending the cantilever less than 2 % of the cantilever length.
AFM Tip:
AFM Cantilever:
Beam
150 µm (140 - 160 µm)*
27 µm (19.5 - 34.5 µm)*
2.8 µm (1.8 - 3.8 µm)*
7.4 N/m (1.2 - 29 N/m)*
160 kHz (75 - 265 kHz)*
* guaranteed range This product features alignment grooves on the back side of the holder chip.
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近日,中科院大连化学物理研究所杨凌团队探索出酶特异性探针底物的研发新策略,该团队采用计算机辅助筛选及酶催化位点局部改造的策略成功设计研发了首个细胞色素P450 1A1亚酶的高特异性荧光探针底物。相关研究成果以“A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a c 查看更多>
AlleleID. It is designed to address the challenge of pathogen detection, species identification and taxa discrimination using TaqMan and molecular beacon assays. With ClustalW multiple sequence alignment at its core, AlleleID can help design universal or taxa/species specific primers and probes. All major qPCR assays including molecular beacons, TaqMan, FRET or SYBR Green are supported. It uses BLAST search to assure specificity. To assure assay success, AlleleID uses template folding to avoid locating primers in the secondary structures of the template.
With AlleleID, you can avoid gDNA by designing primers/probes across exon/exon boundaries. The intron exon regions are identified by interpreting GenBank annotations or by specifying them manually.
To get started quickly with AlleleID, please download and listen to the multi-media tutorial: http://www.PremierBiosoft.com/DATAFILES/AL100Tour.exe.
Then please download the demo version of the program from: http://www.premierbiosoft.com/DATAFILES/AlleleIDTour.exe