NanoWorld Pointprobe® NCH probes are designed for non-contact or tapping™ mode imaging. This probe type combines high operation stability with outstanding sensitivity and fast scanning ability.
All probes of the Pointprobe® series are made from monolithic silicon which is highly doped to dissipate static charge. They are chemically inert and offer a high mechanical Q-factor for high sensitivity. The tip is shaped like a polygon based pyramid.
For applications that require hard contact between tip and sample this probe offers a real diamond tip-side coating. This coating features extremely high wear resistance due to the unsurpassed hardness of diamond.
The typical macroscopic tip radius of curvature lies in the range between 100 and 200 nm. Nanoroughnesses in the 10 nm regime improve the resolution on flat surfaces.
The CDT features a conductive diamond coating. Some typical applications for this tip are Tunneling AFM (Conducting AFM) and Scanning Capacitance Microscopy (SCM).
The conductive diamond coating consists of a 100 nm thick polycrystalline diamond layer deposited on the tip side of the cantilever resulting in an unsurpassed hardness of the tip. The coating is highly doped with boron which leads to a macroscopic resistivity of 0.003 - 0.005 Ohm•cm.
The aluminum reflex coating deposited on the detector side of the cantilever enhances the reflectance of the laser beam and prevents light from interfering within the cantilever.
AFM Tip:
AFM Cantilever:
Beam
125 µm (120 - 130 µm)*
30 µm (25 - 35 µm)*
4 µm (3.5 - 4.5 µm)*
80 N/m (42 - 142 N/m)*
400 kHz (280 - 510 kHz)*
* typical range This product features alignment grooves on the back side of the holder chip.
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近日,中科院大连化学物理研究所杨凌团队探索出酶特异性探针底物的研发新策略,该团队采用计算机辅助筛选及酶催化位点局部改造的策略成功设计研发了首个细胞色素P450 1A1亚酶的高特异性荧光探针底物。相关研究成果以“A practical strategy to design and develop an isoform-specific fluorescent probe for a target enzyme: CYP1A1 as a c 查看更多>
AlleleID. It is designed to address the challenge of pathogen detection, species identification and taxa discrimination using TaqMan and molecular beacon assays. With ClustalW multiple sequence alignment at its core, AlleleID can help design universal or taxa/species specific primers and probes. All major qPCR assays including molecular beacons, TaqMan, FRET or SYBR Green are supported. It uses BLAST search to assure specificity. To assure assay success, AlleleID uses template folding to avoid locating primers in the secondary structures of the template.
With AlleleID, you can avoid gDNA by designing primers/probes across exon/exon boundaries. The intron exon regions are identified by interpreting GenBank annotations or by specifying them manually.
To get started quickly with AlleleID, please download and listen to the multi-media tutorial: http://www.PremierBiosoft.com/DATAFILES/AL100Tour.exe.
Then please download the demo version of the program from: http://www.premierbiosoft.com/DATAFILES/AlleleIDTour.exe