BiologicalActivity
Cell-permeablecAMPanalog;actsasacompetitiveantagonistofcAMP-inducedactivationofPKA(IC50=11-16μM)byinteractingwithcAMPbindingsitesontheregulatorysubunits.Resistanttohydrolysisbyphosphodiesterases.EnantiomercAMPS-Sp,triethylammoniumsalt(Cat.No.1333)alsoavailable.
TechnicalData
| M.Wt | 446.46 |
| Formula | C10H12N5O5PS.C6H15N |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 151837-09-1 |
| PubChemID | 5311365 |
| InChIKey | FKAWLXNLHHIHLA-YCBIHMBMSA-N |
| Smiles | [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 44.65 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight446.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.24mL | 11.2mL | 22.4mL |
| 5mM | 0.45mL | 2.24mL | 4.48mL |
| 10mM | 0.22mL | 1.12mL | 2.24mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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