BiologicalActivity
Inhibitorofhedgehog(Hh)signaling,possIBLyviaseveralmechanisms.InhibitsΔ7-dehydrocholesterolreductase(IC50=13nM),thusreducescholesterolbiosynthesis,andalsoinhibitscholesterolesterification.MayalsodirectlyblockthecellularresponsetoHhproteins.Teratogenicinvivo.
TechnicalData
| M.Wt | 464.3 |
| Formula | C22H28Cl2N2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 366-93-8 |
| PubChemID | 9954082 |
| InChIKey | GZFYZYBWLCYBMI-MYZJJQSMSA-N |
| Smiles | ClC(C=CC=C3)=C3CNC[C@H]1CC[C@H](CNCC2=C(Cl)C=CC=C2)CC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.32 | 5 | |
| water | 23.21 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight464.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.77mL | 21.54mL |
| 5mM | 0.43mL | 2.15mL | 4.31mL |
| 10mM | 0.22mL | 1.08mL | 2.15mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
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