生命科学Tocris价格优惠美国Tocris Bioscience公司,Tocris/AZ 12080282 dihydrochloride/4838/50/50 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/AZ 12080282 dihydrochloride/4838/50/50 mg

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Tocris/AZ 12080282 dihydrochloride/4838/50/50 mg

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Tocris

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4838/50

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4000-520-616

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Description:InhibitorofHedgehog(Hh)signaling

ChemicalName:N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamidedihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHedgehog(Hh)signaling(IC₅₀<0.012μMinafireflyreporterassayagainsttheHhpathway).ShowntodisplacecyclopamineinHeLacellsexpressingSmoothened.Exhibitsselectivityagainstp38α.Orallybioavailable.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

AZ12080282dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	457.35
Formula	C₂₃H₂₀N₄O₂.2HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
PubChemID	78243727
InChIKey	CPORFOBFIDPDLZ-UHFFFAOYSA-N
Smiles	CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	45.73	100
	water	45.73	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight457.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.19mL	10.93mL	21.87mL
5mM	0.44mL	2.19mL	4.37mL
10mM	0.22mL	1.09mL	2.19mL
50mM	0.04mL	0.22mL	0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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