BiologicalActivity
Rho/SRFpathwayinhibitor;stimulatesapoptosisofamelanomacelllineoverexpressingRhoC(A375M2).SuppressesRho-dependentinvasionofPC-3prostatecancercellsinvitroandinhibitslysophosphatidicacid-inducedDNAsynthesisinPC-3prostatecancercells.WhenusedincombinationwithRetinoicacid,LY294002andPyridone6,itinducesintermediatemesodermdifferentiationfromESCs.
CompoundLibraries
CCG1423isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 454.75 |
| Formula | C18H13ClF6N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 285986-88-1 |
| PubChemID | 2726015 |
| InChIKey | DSMXVSGJIDFLKP-UHFFFAOYSA-N |
| Smiles | O=C(NOC(C)C(NC2=CC=C(Cl)C=C2)=O)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.48 | 100 | |
| ethanol | 4.55 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight454.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.2mL | 11mL | 21.99mL |
| 5mM | 0.44mL | 2.2mL | 4.4mL |
| 10mM | 0.22mL | 1.1mL | 2.2mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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