BiologicalActivity
Maintainsembryonicstemcell(ESC)pluripotencyinWnt3a-treatedcells;enablesWnt/β-catenin-drivenexpansionofmouseESCsandpreventsspontaneousdifferentiation.UpregulatesexpressionofOct4andSox2transcriptionfactors.Bindstoserine/threoninephosphatasePP2AandpreventsPP2A/Nkdinteraction.
CompoundLibraries
IQ1isalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 362.42 |
| Formula | C21H22N4O2 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 331001-62-8 |
| PubChemID | 56801 |
| InChIKey | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
| Smiles | CC(C(C=C3)=CC=C3/N=N/C(C(N)=O)=C2C1=CC=CC=C1CC(C)(C)N2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.24 | 100 | |
| ethanol | 7.25 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight362.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.76mL | 13.8mL | 27.59mL |
| 5mM | 0.55mL | 2.76mL | 5.52mL |
| 10mM | 0.28mL | 1.38mL | 2.76mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
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