BiologicalActivity
Selectiveinducerofneuronaldifferentiation;inducesneuronaldifferentiationinculturedhippocampalneuralprogenitorcells(NPCs)byinteractingwithTACC3(EC50~1μM).Suppressesastrocyteformation.Alsoinducesaccelerationofneuronaldifferentiationinthehippocampaldentategyrusinvivo.
CompoundLibraries
KHS101hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 375.92 |
| Formula | C18H21N5S.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| PubChemID | 90488983 |
| InChIKey | INVQHPQJFRKGIO-UHFFFAOYSA-N |
| Smiles | CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.8 | 50 | |
| ethanol | 18.8 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight375.92.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.3mL | 26.6mL |
| 5mM | 0.53mL | 2.66mL | 5.32mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
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ProductDatasheets
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