BiologicalActivity
Anticanceragent.InducesG2/McellcyclearrestandapoptosisinA549cellsthroughJNK-dependentp53Ser15phosphorylation;inhibitsA549andMDA-MD-231tumourxenograftgrowthinnudemice.PromotesautophagiccelldeathinMDA-MB-231andMCF-7cellsandinhibitsAkt/mTORsignaling.InducesintracellularROSgenerationinaPI5-kinase-dependentmanner.Alsoinhibitsp300-mediatedacetylationofp53.
TechnicalData
| M.Wt | 188.18 |
| Formula | C11H8O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 481-42-5 |
| PubChemID | 10205 |
| InChIKey | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
| Smiles | CC2=CC(C1=C(C2=O)C=CC=C1O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.82 | 100 | |
| ethanol | 9.41 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight188.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.31mL | 26.57mL | 53.14mL |
| 5mM | 1.06mL | 5.31mL | 10.63mL |
| 10mM | 0.53mL | 2.66mL | 5.31mL |
| 50mM | 0.11mL | 0.53mL | 1.06mL |
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