品牌试剂实验Tocris代理 Tocris神经传递素,Tocris/Netilmicin sulfate/6339/10/10 mg,临床研究,其它试剂,其它,,Tocris Bioscience蚂蚁淘商城

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Tocris/Netilmicin sulfate/6339/10/10 mg

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Tocris

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6339/10

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Description:InhibitsHIV-1replication;alsosemisyntheticaminoglycosideantibiotic

ChemicalName:O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arABInopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-N¹-ethyl-D-streptaminesestersulfate

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Bindsthetransactivationresponseelement(TAR)ofHIV-1(K_d=1.35μM)andinhibitsitsinteractionwithTat.Exhibits>35-foldselectivityforHIV-1TARoverHIV-2TARorA-siteandRRERNA.InhibitsTat-mediatedHIV-1activationandreplicationinT-cellsinvitro.Alsosemisyntheticaminoglycosideantibiotic.

TechnicalData

M.Wt	720.78
Formula	C₂₁H₄₁N₅O₇.2.5H₂SO₄
Storage	DesiccateatRT
CASNumber	56391-57-2
PubChemID	62115
InChIKey	AGFWIZQEWFGATK-UNZHCMSXSA-N
Smiles	OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.[H][C@@]1(OC(CN)=CC[C@H]1N)O[C@@H]2[C@H](C[C@H]([C@@H]([C@H]2O)O[C@]3(OC[C@](O)([C@@H]([C@H]3O)NC)C)[H])NCC)N.[H][C@@]4(OC(CN)=CC[C@H]4N)O[C@@H]5[C@H](C[C@H]([C@@H]([C@H]5O)O[C@]6(OC[C@](O)([C@@H]([C@H]6O)NC)C)[H])NCC)N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	water	72.08	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight720.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.39mL	6.94mL	13.87mL
5mM	0.28mL	1.39mL	2.77mL
10mM	0.14mL	0.69mL	1.39mL
50mM	0.03mL	0.14mL	0.28mL

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